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Effect of follicle-stimulating hormone and its antiserum on the activity of ornithine decarboxylase in the ovary of rat and hamster

Sheela Rani, CS and Moudgal, NR (1979) Effect of follicle-stimulating hormone and its antiserum on the activity of ornithine decarboxylase in the ovary of rat and hamster. In: Endocrinology, 104 (5). pp. 1480-1483.

Full text not available from this repository.
Official URL: http://www.ncbi.nlm.nih.gov/pubmed/571330

Abstract

The ability of FSH to stimulate the activity of ornithine decarboxylase (ODC) in the ovary of the immature rat and cycling hamster has been examined using specific antisera to gonadotropins. The stimulatory effect of FSH on ODC activity in the ovary of the immature rat was abolished when LH antiserum was administered along with FSH, while similar administration of FSH antiserum had no effect on LH action in stimulating ODC activity, thereby demonstrating the specificity of the LH effect. During the estrus cycle of the hamster, ODC activity in the ovary could be detected only on the evening of proestrus, the maximal activity seen at 1700 h being associated with both the Graafian follicles and the rest of the ovarian tissue. Neutralization of the proestrous FSH surge had no effect on the activity of ODC in either of these tissues, while similar administration of LH antiserum at 1300 h of proestrus completely inhibited the ODC activity in both large follicles and the rest of the ovarian tissue. Thus, the surge of LH, but not of FSH, appears to be responsible for regulating the ODC activity in the ovary of the cycling hamster.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Endocrinology.
Department/Centre: Others
Date Deposited: 19 Oct 2010 07:13
Last Modified: 19 Oct 2010 07:13
URI: http://eprints.iisc.ernet.in/id/eprint/33301

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