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Effect of phenyl and phenolic acids on mevalonate-5-Phosphate decarboxylase if the brain

Bhat, Charavu Shama and Ramasarma, T (1979) Effect of phenyl and phenolic acids on mevalonate-5-Phosphate decarboxylase if the brain. In: Journal of Neurochemistry, 32 (5). pp. 1531-1537.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1471-...

Abstract

Phenyl and phenolic acids are known to inhibit metabolism of mevalonate in rat brain. The site of inhibition has been found to be mevalonate-5-pyrophosphate decarboxylase. Phenolic acids also inhibited mevalonate-5-phosphate kinase on preincubation. The kinetics showed that p-coumaric acid and isoferulic acid were competing with substrates, mevalonate-5-phosphate or mevalonate-5-pyre phosphate, whereas others showed an uncompetitive type of inhibition. Chlorophenoxyisobutyrate, a hypocholesterolaemic drug, had no effect on these enzymes. An improved method for the synthesis of mevalonate-5-phosphate and mevalonate-5-pyrophosphate, labeled at carbon-1, is described.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 19 Oct 2010 07:10
Last Modified: 19 Oct 2010 07:10
URI: http://eprints.iisc.ernet.in/id/eprint/33303

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