Bhat, Charavu Shama and Ramasarma, T (1979) Effect of phenyl and phenolic acids on mevalonate-5-Phosphate decarboxylase if the brain. In: Journal of Neurochemistry, 32 (5). pp. 1531-1537.Full text not available from this repository.
Phenyl and phenolic acids are known to inhibit metabolism of mevalonate in rat brain. The site of inhibition has been found to be mevalonate-5-pyrophosphate decarboxylase. Phenolic acids also inhibited mevalonate-5-phosphate kinase on preincubation. The kinetics showed that p-coumaric acid and isoferulic acid were competing with substrates, mevalonate-5-phosphate or mevalonate-5-pyre phosphate, whereas others showed an uncompetitive type of inhibition. Chlorophenoxyisobutyrate, a hypocholesterolaemic drug, had no effect on these enzymes. An improved method for the synthesis of mevalonate-5-phosphate and mevalonate-5-pyrophosphate, labeled at carbon-1, is described.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to John Wiley and Sons.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||19 Oct 2010 07:10|
|Last Modified:||19 Oct 2010 07:10|
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