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A possible role for a low molecular weight peptide in regulation of testosterone production by rat Leydig cells

Ramaraj, P and Subbarayan, VSR and Jagannadha, RA (1991) A possible role for a low molecular weight peptide in regulation of testosterone production by rat Leydig cells. In: Indian Journal of Biochemistry & Biophysics, 28 (5-6). pp. 536-540.

Full text not available from this repository.
Official URL: http://www.ncbi.nlm.nih.gov/pubmed/1812092

Abstract

Sodium dodecyl sulphate-polyacrylamide gel electrophoresis of Percoll purified Leydig cell proteins from 20- and 120-day-old rats revealed a significant decrease in a low molecular weight peptide in the adult rats. Administration of human chorionic gonadotropin to immature rats resulted in a decrease in the low molecular weight peptide along with increase in testosterone production. Modulation of the peptide by human chorionic gonadotropin could be confirmed by Western blotting. The presence of a similar peptide could be detected by Western blotting in testes of immature mouse, hamster, guinea pig but not in adrenal, placenta and corpus luteum. Administration of testosterone propionate which is known to inhibit the pituitary luteinizing hormone levels in adult rats resulted in an increase in the low molecular weight peptide, as checked by Western blotting. It is suggested that this peptide may have a role in regulation of acquisition of responsiveness to luteinizing hormone by immature rat Leydig cells.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 11 Nov 2010 07:09
Last Modified: 11 Nov 2010 07:09
URI: http://eprints.iisc.ernet.in/id/eprint/33630

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