Mehta, Goverdhan and Roy, Subhrangsu (2005) Enantioselective total synthesis of a novel polyketide natural product(+)-integrasone, an HIV-1 integrase inhibitor. In: Chemical Communications (25). pp. 3210-3212.
Enantioselective total synthesis of the recently isolated, novel polyketide natural product (+)-integrasone has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. An enzymatically desymmetrized epoxyquinone building block has been elaborated through a series of regio-, chemo- and stereocontrolled steps to the final bicyclic framework of the natural product.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Royal Society of Chemistry.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||21 Jul 2005|
|Last Modified:||19 Sep 2010 04:19|
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