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Enantioselective total synthesis of a novel polyketide natural product(+)-integrasone, an HIV-1 integrase inhibitor

Mehta, Goverdhan and Roy, Subhrangsu (2005) Enantioselective total synthesis of a novel polyketide natural product(+)-integrasone, an HIV-1 integrase inhibitor. In: Chemical Communications (25). pp. 3210-3212.

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Abstract

Enantioselective total synthesis of the recently isolated, novel polyketide natural product (+)-integrasone has been accomplished from the readily available Diels-Alder adduct of cyclopentadiene and p-benzoquinone. An enzymatically desymmetrized epoxyquinone building block has been elaborated through a series of regio-, chemo- and stereocontrolled steps to the final bicyclic framework of the natural product.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Royal Society of Chemistry.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 21 Jul 2005
Last Modified: 19 Sep 2010 04:19
URI: http://eprints.iisc.ernet.in/id/eprint/3369

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