Madyastha, KM and Raj, Paul C (1991) Evidence for the formation of a known toxin, P-cresol, from menthofuran. In: Biochemical and Biophysical Research Communications, 177 (1). 440-446 .
EVIDENCE_FOR_THE_FORMATION_OF_A.pdf - Published Version
Restricted to Registered users only
Download (326Kb) | Request a copy
Menthofuran (II, 4,5,6,7-tetrahydro-3,6-dimethyl benzofuran), the proximate toxin of R-(+)-pulegone (I), was administered orally to rats (200 mg/kg of body weight/day) for three days and the urinary metabolites were investigated. Among the several metabolites formed, two of them viz. 4-Hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) were indentified. In support of the formation of these metabolites, it has been demonstrated that phenobarbital induced rat liver microsomes readily convert 4-methyl-2-cyclohexenone (V) to 4-hydroxy-4-methyl-2-cyclohexenone (VII) and p-cresol (VIII) in the presence of NADPH and O2. Possible mechanism for the formation of these two metabolites (VII, VIII) from menthofuran (II) has been proposed.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier science.|
|Keywords:||Pennyroyal Oil;Hepatotoxicity;Pulegone;Mouse; R)-(+)-Pulegone;Metabolism;Proteins;Invivo|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||30 Nov 2010 08:12|
|Last Modified:||30 Nov 2010 08:12|
Actions (login required)