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A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein

Klug, A and Jack, A and Viswamitra, MA and Kennard, Olga and Shakked, Z and Steitz, TA (1979) A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein. In: Journal of Molecular Biology, 131 (4). pp. 669-680.

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Official URL: http://dx.doi.org/10.1016/0022-2836(79)90196-7

Abstract

The structure and properties of the double-helical form of the alternating copolymer poly(dA-dT) are considered. Different lines of evidence are interpreted in terms of a structure in which every second phosphate-diester linkage has a conformation different from that of the normal B form. A rationale for this “alternating-B” structure is given which provides an explanation for the effects of chemical modifications of the T residues on the binding of the poly(dA-dT)· poly(dA-dT) to the lac repressor of Escherichia coli.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Department/Centre: Others
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 22 Dec 2010 10:55
Last Modified: 22 Dec 2010 10:55
URI: http://eprints.iisc.ernet.in/id/eprint/34394

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