Klug, A and Jack, A and Viswamitra, MA and Kennard, Olga and Shakked, Z and Steitz, TA (1979) A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein. In: Journal of Molecular Biology, 131 (4). pp. 669-680.
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The structure and properties of the double-helical form of the alternating copolymer poly(dA-dT) are considered. Different lines of evidence are interpreted in terms of a structure in which every second phosphate-diester linkage has a conformation different from that of the normal B form. A rationale for this “alternating-B” structure is given which provides an explanation for the effects of chemical modifications of the T residues on the binding of the poly(dA-dT)· poly(dA-dT) to the lac repressor of Escherichia coli.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
Division of Physical & Mathematical Sciences > Physics
|Date Deposited:||22 Dec 2010 10:55|
|Last Modified:||22 Dec 2010 10:55|
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