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Glycodelin A suppresses the cytolytic activity of CD8(+) T lymphocytes

Soni, Chetna and Karande, Anjali A (2010) Glycodelin A suppresses the cytolytic activity of CD8(+) T lymphocytes. In: Molecular Immunology, 47 (15). pp. 2458-2466.

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Official URL: http://dx.doi.org/10.1016/j.molimm.2010.06.008

Abstract

Maternal tolerance to the semi-allogenic fetus is brought about by several mechanisms in humans Glycodelin A (GdA) secreted by the uterine mucosa and decidua is induced to high levels by progesterone between 12 and 16 weeks of pregnancy The glycoprotein an immunomodulator has been shown to be inhibitory to the survival and functions of almost all the immune cells CD8(+) T cells which predominate the T lymphocyte population in the decidua are relatively less studied We attempted to find out the possible mechanism if any of regulation of the cytolytic function of CD8(+) T cells during pregnancy Alloactivated CD8(+) T cells harbouring specific cytolytic activity against target cells exhibited compromised activity upon treatment with high concentrations of GdA Interestingly unlike the CD4(+) T cells CD8(+) T cells were resistant to GdA-induced apoptosis The inhibition of cytotoxic T lymphocyte activity was brought about by the downregulation of transcription of the cytolytic effector molecules granzyme B and perform and the degranulation of cytolytic vesicles These results suggest a protective role played by GdA during pregnancy by regulating the cytolytic activity of CD8(+) T cells (C) 2010 Elsevier Ltd All rights reserved

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Fetal tolerance; Glycodelin A; cytotoxic T lymphocytes; Granzyme; Perforin
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 13 Dec 2010 10:24
Last Modified: 13 Dec 2010 10:24
URI: http://eprints.iisc.ernet.in/id/eprint/34446

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