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Immediate hypersensitivity to Parthenium hysterophorus. I. Association of HLA antigens and Parthenium rhinitis

Sriramarao, P and Selvakumar, B and Damodaran, C and RAO, BSS and Prakash, O and Rao, PVS (1990) Immediate hypersensitivity to Parthenium hysterophorus. I. Association of HLA antigens and Parthenium rhinitis. In: Clinical and Experimental Allergy, 20 (5). pp. 555-560.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-...

Abstract

Lymphocytes collected from rhinitis subjects with strong positive skin reactions to the pollen allergens of Parthenium hysterophorus (American feverfew) having moderate to high titres of Parthenium-specific serum IgE were analysed for association of HLA-antigens covering 13 specificities of HLA-A, 17 specificities of HLA-B and eight specificities of HLA-DR loci by the NIH two-stage microlymphocytotoxicity assay. Comparison of the phenotypic frequencies of HLA-A and B antigens between Parthenium rhinitis subjects (n= 22) and control subjects (n= 137) did not suggest any significant association when tested for these antigen specificities. A significant correlation in the association of HLA-DR3 antigen with a relative risk of 11·33, however, was observed in Parthenium rhinitis subjects (n= 30) when compared to controls (n= 50).

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley & Sons.
Department/Centre: Division of Biological Sciences > Biochemistry
Others
Date Deposited: 26 Apr 2011 10:41
Last Modified: 26 Apr 2011 10:41
URI: http://eprints.iisc.ernet.in/id/eprint/35063

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