ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Chronic suppression of testicular function by constant infusion of gonadotropin-releasing hormone agonist and testosterone supplementation in the bonnet monkey (Macaca radiata)

Srikrishna, A and Sharma, GVR and Nagaraju, S (1992) Chronic suppression of testicular function by constant infusion of gonadotropin-releasing hormone agonist and testosterone supplementation in the bonnet monkey (Macaca radiata). In: Fertility and Sterility, 57 (3). pp. 671-676.

Full text not available from this repository.
Official URL: http://www.biomedsearch.com/nih/Chronic-suppressio...

Abstract

Objective: To study the efficacy of long-term buserelin acetate infusion to desensitize pituitary and block testicular function in adult male monkeys (Macaca radiata). Animals: Proven fertile male monkeys exhibiting normal testicular function. Protocol: Each of the control (n = 5) and experimental monkeys (n = 10) received a fresh miniosmotic pump every 21 days, whereas pumps in controls delivered vehicle of experimentals released 50-mu-g buserelin acetate every 24 hours. On day 170 (renewed every 60 days) a silastic capsule containing crystalline testosterone (T) was implanted in the experimental monkeys. At the end of 3 years, treatment was stopped, and recovery of testicular function and fertility monitored. Results: (1) Treatment resulted in marked reduction of nocturnal but not basal serum T; (2) the pituitary remained desensitized to buserelin acetate throughout the 3-year period; (3) animals were largely azoospermic with occasional oligospermia exhibited by two monkeys; and (4) withdrawal of treatment restored testicular function, with 70% of animals regaining fertility. Conclusion: Long-term infertility (but restorable) can be induced in male monkeys by constant infusion of buserelin acetate and T.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier science.
Keywords: Male Infertility;Buserelin;Pituitary Desensitization;Monkey Testicular Function.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 25 Jan 2011 06:45
Last Modified: 25 Jan 2011 06:45
URI: http://eprints.iisc.ernet.in/id/eprint/35131

Actions (login required)

View Item View Item