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devovo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite

Surolia, Namita and Padmanaban, Govindarajan (1992) devovo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite. In: Biochemical and Biophysical Research Communications, 187 (2). pp. 744-750.

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Official URL: http://dx.doi.org/10.1016/0006-291X(92)91258-R

Abstract

The human malarial parasite, Image , has been found to synthesize heme Image , despite the accumulation of large quantities of polymeric heme derived from the hemoglobin of the red cell host. The parasite δ-aminolevulinate dehydrase level is significantly lower than that of the host and its inhibition by succinylacetone leads to inhibition of parasite protein synthesis and viability.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier science.
Department/Centre: Division of Biological Sciences > Biochemistry
Others
Date Deposited: 25 Jan 2011 04:58
Last Modified: 25 Jan 2011 04:58
URI: http://eprints.iisc.ernet.in/id/eprint/35162

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