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Effect of constant infusion of gonadotropin releasing hormone (GnRH) agonist Buserelin and antagonist CDB 2085 A using osmotic minipumps on testicular function in adult male bonnet monkey (Macaca radiata)

Rao, Jagannadha A and Chakraborti, R and Kotagi, SG and Ravindranath, N (1990) Effect of constant infusion of gonadotropin releasing hormone (GnRH) agonist Buserelin and antagonist CDB 2085 A using osmotic minipumps on testicular function in adult male bonnet monkey (Macaca radiata). In: Andrologia, 22 (6). pp. 567-573.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1439-...

Abstract

The effect of chronic infusion of gonadotropic hormone agonist Buserelin or antagonist CDB 2085 A for 15 weeks via alzet minipumps in adult male bonnet monkeys was studied. Infusion of Buserelin resulted in a decrease in the difference between serum testosterone values at 22.00 hours and 10.00 hours, decrease in responsiveness to injected Buserelin as judged by change in serum testosterone values from pre-injection values and decrease in sperm counts. Infusion of antagonist resulted in a decrease in the difference between serum testosterone values at 22.00 hours and 10.00 hours.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: GnRH;constant infusion;Buserelin;testicular function;testis function;GnRH
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 10 Feb 2011 10:11
Last Modified: 10 Feb 2011 10:11
URI: http://eprints.iisc.ernet.in/id/eprint/35164

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