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Do the Hydrolysis Products, Methylamine and N,N'-Dimethylurea, Play any Role in the Methyl Isocyanate-Induced Haematological and Biochemical Changes in Rabbits?

Jeevaratnam, K and Sugendran, K and Vaidyanathan, CS (1993) Do the Hydrolysis Products, Methylamine and N,N'-Dimethylurea, Play any Role in the Methyl Isocyanate-Induced Haematological and Biochemical Changes in Rabbits? In: Human Toxicology, 12 (2). pp. 135-139.

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Official URL: http://het.sagepub.com/content/12/2/135.abstract

Abstract

The subcutaneous administration of methyl isocyanate (MIC) to female rabbits, resulted in significant increases in haemoglobin concentration, erythrocyte volume fraction and leucocyte number in blood, as well as plasma total proteins, and urea. The present study was designed to investigate whether the hydrolytic products of MIC, methylamine (MA) and N,N'-dimethylurea (DMU) play any role in eliciting these changes. Both MA and DMU administered subcutaneously in an equimolar dose to that of 1.0 LD50 MIC, 2.2 mmol kg-1, had no influence on these parameters, although there was a marginal increase in the plasma urea level shortly after the administration of DMU. This study establishes that the observed haematological and biochemical changes induced by MIC intoxication in rabbits are mostly due to MIC.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Stockton Press.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 10 Feb 2011 09:47
Last Modified: 10 Feb 2011 09:47
URI: http://eprints.iisc.ernet.in/id/eprint/35406

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