Phadnis, Prasad P and Mugesh, G (2005) Internally Stabilized Selenocysteine Derivatives: Syntheses, $^7^7$Se NMR and Biomimetic Studies. In: Organic and Biomolecular Chemistry, 3 (13). pp. 2476-2481.
Selenocystine $([Sec]_2)$ and aryl-substituted selenocysteine (Sec) derivatives are synthesized, starting from commercially available amino acid L-serine. These compounds are characterized by a number of analytical techniques such as NMR $(^1H, ^1^3C and ^7^7Se)$ and TOF mass spectroscopy. This study reveals that the introduction of amino/imino substituents capable of interacting with selenium may stabilize the Sec derivatives. This study further suggests that the oxidation-elimination reactions in Sec derivatives could be used for the generation of biologically active selenols having internally stabilizing substituents.
|Item Type:||Journal Article|
|Additional Information:||The copyright for this article belongs to Royal Society of Chemistry|
|Department/Centre:||Division of Chemical Sciences > Inorganic & Physical Chemistry|
|Date Deposited:||30 Sep 2005|
|Last Modified:||19 Sep 2010 04:19|
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