Mukherjee, Arindam and Dhar, Shanta and Nethaji, Munirathinam and Chakravarty, Akhil R (2005) Ternary iron(II) complex with an emissive imidazopyridine arm from Schiff base cyclizations and its oxidative DNA cleavage activity. In: Dalton Transactions (2). pp. 349-353.
The ternary iron(II) complex [Fe(L')(L")] $(PF_6)_3(1)$ as a synthetic model for the bleomycins, where L' and L" are formed from metal-mediated cyclizations of N,N -(2-hydroxypropane-1,3-diyl)bis(pyridine-2-aldimine)(L), is synthesized and structurally characterized by X-ray crystallography. In the six-coordinate iron(II) complex, ligands L' and L" show tetradentate and bidentate chelating modes of bonding. Ligand L' is formed from an intramolecular attack of the alcoholic OH group of L to one imine moiety leading to the formation of a stereochemically constrained five-membered ring. Ligand L" which is formed from an intermolecular reaction involving one imine moiety of L and pyridine-2-carbaldehyde has an emissive cationic imidazopyridine pendant arm. The complex binds to double-stranded DNA in the minor groove giving a $K_a_p_p$ value of 4.1 x $10^5 M^Ã¢â�¬â��^1$ and displays oxidative cleavage of supercoiled DNA in the presence of $H_2O_2$ following a hydroxyl radical pathway. The complex also shows photo-induced DNA cleavage activity on UV light exposure involving formation of singlet oxygen as the reactive species.
|Item Type:||Journal Article|
|Additional Information:||The copyright for this article belongs to Royal Society of Chemistry.|
|Department/Centre:||Division of Chemical Sciences > Inorganic & Physical Chemistry|
|Date Deposited:||21 Sep 2005|
|Last Modified:||19 Sep 2010 04:19|
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