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Is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation?

Maiti, Prasanta Kumar and Kar, Anand (1998) Is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation? In: Journal of Applied Toxicology, 18 (2). pp. 125-128.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/%28SICI...

Abstract

A study on the effect of triiodothyronine ($T_3$) in the regulation of pyrethroid (fenvalerate) induced thyroid dysfunction and lipid peroxidation was carried out in male mice. Fenvalerate (120 mg ${kg}^{-1}$ body wt. daily for 15 days) administration led to a decrease in the serum concentration of thyroid hormones and the activity of hepatic type I iodothyronine 5'-monodeiodinase (5' D-I) and an increase in the level of lipid peroxidation. The decrease in the activity of hepatic 5' D-I due to the administration of fenvalerate was restored with the administration of $T_3$ (7 \mu g ${kg}^{-1}$ body wt. on alternate days). The increased level of lipid peroxidation was also ameliorated by $T_3$. However, $T_3$ could not restore the serum concentration of thyroxine ($T_4$), only that of $T_3$. We suggest that the ameliorating role of T3 in the fenvalerate-intoxicated mice could be the result of the lipogenic action of the thyroid hormone, which in turn led to the restoration of 5'D-I activity.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley & Sons.
Keywords: pyrethroid;fenvalerate;triiodothyronine;monodeiodination;lipid peroxidation;superoxide dismutase;catalase;mice
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 19 Jan 2007
Last Modified: 08 Feb 2012 06:48
URI: http://eprints.iisc.ernet.in/id/eprint/3598

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