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Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids

Babu, Ponnusamy and Maitra, Uday (2005) Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids. In: Steroids, 70 (10). pp. 681-689.

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Abstract

A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increase in the bulk pH.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Elsevier.
Keywords: Bile acids;Cholesterol dissolution;Gallstone dissolution;Phosphonobile acids
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 05 Sep 2005
Last Modified: 19 Sep 2010 04:20
URI: http://eprints.iisc.ernet.in/id/eprint/3610

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