Babu, Ponnusamy and Maitra, Uday (2005) Synthesis and in vitro cholesterol dissolution by 23- and 24-phosphonobile acids. In: Steroids, 70 (10). pp. 681-689.
A new class of 23- and 24-phosphonobile acids have been synthesized from bile acid and their in vitro cholesterol-dissolving efficiency have been estimated. 24-Phosphonobile salts (PBSs) are slightly more efficient in solubilizing cholesterol than 23-PBSs and natural bile salts. The cholesterol solubilizing power is influenced by the structure of PBSs, and is considerably reduced with an increase in the bulk pH.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Elsevier.|
|Keywords:||Bile acids;Cholesterol dissolution;Gallstone dissolution;Phosphonobile acids|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||05 Sep 2005|
|Last Modified:||19 Sep 2010 04:20|
Actions (login required)