Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes, in vivo

Madyastha, KM and Raj, CP (1994) Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes, in vivo. In: Toxicology, 89 (2). 119 -125 .

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Abstract

Oral administration (250 mg/kg) of menthofuran, a monoterpene furan, to rats once daily for 3 days caused hepatotoxicity as judged by a significant increase in serum glutamate pyruvate transaminase (SGPT) and decreases in glucose-6-phosphatase and aminopyrine N-demethylase activities. Administration of menthofuran also resulted in a decrease in the levels of liver microsomal cytochrome P-450, whereas cytochrome b(5) and NAD(P)H-cytochrome c reductase activities were not affected. These effects of menthofuran were both dose- and time-dependent. Pretreatment of rats with phenobarbital (PB) prior to menthofuran treatment potentiated hepatotoxicity suggesting that a PB-induced cytochrome P-450 catalyzed the formation of reactive metabolite(s) responsible for the hepatotoxicity.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to Elsevier Science.
Keywords:	Menthofuran;pulegone; ytochrome P-450;hepatotoxicity; Microsomal enzymes;Serum glutamate pyruvate transaminase
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	31 May 2011 10:28
Last Modified:	31 May 2011 10:28
URI:	http://eprints.iisc.ernet.in/id/eprint/36437

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