Madyastha, KM and Raj, CP (1994) Effects of menthofuran, a monoterpene furan on rat liver microsomal enzymes, in vivo. In: Toxicology, 89 (2). 119 -125 .
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Oral administration (250 mg/kg) of menthofuran, a monoterpene furan, to rats once daily for 3 days caused hepatotoxicity as judged by a significant increase in serum glutamate pyruvate transaminase (SGPT) and decreases in glucose-6-phosphatase and aminopyrine N-demethylase activities. Administration of menthofuran also resulted in a decrease in the levels of liver microsomal cytochrome P-450, whereas cytochrome b(5) and NAD(P)H-cytochrome c reductase activities were not affected. These effects of menthofuran were both dose- and time-dependent. Pretreatment of rats with phenobarbital (PB) prior to menthofuran treatment potentiated hepatotoxicity suggesting that a PB-induced cytochrome P-450 catalyzed the formation of reactive metabolite(s) responsible for the hepatotoxicity.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Keywords:||Menthofuran;pulegone; ytochrome P-450;hepatotoxicity; Microsomal enzymes;Serum glutamate pyruvate transaminase|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||31 May 2011 10:28|
|Last Modified:||31 May 2011 10:28|
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