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Utility of microbes in organic-synthesis - selective transformations of acyclic isoprenoids by aspergillus-niger

Madyastha, KM and Gururaja, TL (1993) Utility of microbes in organic-synthesis - selective transformations of acyclic isoprenoids by aspergillus-niger. In: Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry, 32 (6). pp. 609-614.

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Official URL: http://www.niscair.res.in/ScienceCommunication/Res...

Abstract

Bioconversion of acyclic isoprenoids using a strain of Aspergillus niger results in hydroxylated metabolites with regio- and stereoselectivity. The organism carries out oxidation of the terminal allylic methyl group and the remote double bond in all the compounds tested (I-VII). However, these two activities seem to have preferential structural requirements. When an acyclic isoprenoid with a ketone functionality such as geranylacetone is used as the substrate, the organism also carries out the asymmetric reduction of the keto group. All the metabolites formed have been purified and characterized by conventional spectroscopic methods and quantification has been made by gas chromatographic analyses.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to National Institute of Science Communication and Information Resources.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 26 Apr 2011 10:21
Last Modified: 26 Apr 2011 10:21
URI: http://eprints.iisc.ernet.in/id/eprint/36452

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