Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA

Prasad, Puja and Khan, Imran and Sasmal, Pijus K and Koley, Debasis and Kondaiah, Paturu and Chakravarty, Akhil R (2011) Planar triazinium cations from VO2+-assisted ring cyclizations: a remarkably efficient thiazole species for nuclear staining, PDT and anaerobic photocleavage of DNA. In: Chemical Communications, 47 (13). pp. 3954-3956.

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Abstract

Planar triazinium cationic species, from VO2+-assisted cyclization of 1-(2-thiazolylazo)-2-naphthol, shows efficient DNA intercalative binding, visible light-induced anaerobic plasmid DNA photocleavage activity and photocytotoxicity in HeLa and MCF-7 cancer cells by an apoptotic pathway with selective localization of the compound in the nucleus as evidenced from the nuclear staining and confocal imaging.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME) Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	06 Apr 2011 09:24
Last Modified:	06 Apr 2011 09:24
URI:	http://eprints.iisc.ernet.in/id/eprint/36611

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