DSouza, Lawrence J and Maitra, Uday (1996) Design, synthesis, and evaluation of bile acid-based molecular tweezers. In: Journal of Organic Chemistry, 61 (26). pp. 9494-9502.
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A family of bile acid-based molecular tweezers (7-9) has been constructed readily from simple precursors. Binding experiments with various electron deficient aromatic compounds showed that tweezer 8 binds trinitrofluorenone 10e with an association constant of 220 M(-1) in CDCl3. Single-crystal X-ray analysis of compound 8 shows aromatic-aromatic interactions producing a two-dimensional lattice of pyrene units. Tweezer 8 was immobilized on Merrifield resin, and binding studies have shown that these data compare well with those of the solution state studies.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to American chemical society.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||07 May 2011 05:49|
|Last Modified:||07 May 2011 05:49|
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