Kraemer, Nadine and Issa, Lina and Hauck, Stefanie CR and Mani, Shyamala and Ninnemann, Olaf and Kaindl, Angela M (2011) What's the hype about CDK5RAP2? In: Cellular and Molecular Life Sciences, 68 (10). pp. 1719-1736.
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Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. This disease is seen as an isolated developmental defect of the brain, particularly of the cerebral cortex, and was thus historically also referred to as microcephalia vera. Unraveling the pathomechanisms leading to this human disease is fascinating scientists because it can convey insight into basic mechanisms of physiologic brain development (particularly of cortex formation). It also finds itself in the spotlight because of its implication in trends in mammalian evolution with a massive increase in the size of the cerebral cortex in primates. Here, we provide a timely overview of the current knowledge on the function of CDK5RAP2 and mechanisms that might lead to disease in humans when the function of this protein is disturbed.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Springer.|
|Keywords:||Microcephaly;MCPH;CDK5RAP2;CDK5;Centrosome;Spindle;Cell cycle;Mental retardation|
|Department/Centre:||Division of Biological Sciences > Centre for Neuroscience|
|Date Deposited:||20 May 2011 07:06|
|Last Modified:||20 May 2011 07:06|
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