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Influence of cadmium on lipid peroxidation and antioxidant enzymes in isolated rat hepatocytes

Sarkar, S and Yadav, P and Bhatnagar, D (1998) Influence of cadmium on lipid peroxidation and antioxidant enzymes in isolated rat hepatocytes. In: Fresenius Environmental Bulletin, 7 (1-2). pp. 28-33.

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Official URL: http://www.psp-parlar.de/

Abstract

Cadmium (Cd) influences lipid peroxidation (LPO) by enhancing peroxidation of membrane lipids and by disturbing the antioxidant system of cells. In isolated rat hepatocytes, LPO was observed in cells incubated with Cd (50-250 mu M) for various time periods up to 90 min. The antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) were inhibited along with depletion of glutathione (GSH) in hepatocytes treated with Cd. The results show that Cd influences LPO in rat hepatocytes due to decrease in antioxidant status.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Inst Lebensmitteltechnologie Analytische Chemie.
Keywords: cadmium;lipid peroxidation;superoxide dismutase;catalase; glutathione;hepatocytes.
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Date Deposited: 09 Jun 2011 07:00
Last Modified: 15 Jan 2013 06:52
URI: http://eprints.iisc.ernet.in/id/eprint/38118

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