Vempati, UD and Kondaiah, P (1998) Molecular organization of the gene encoding Xenopus laevis transforming growth factor-beta 5. In: Biochemistry & Molecular Biology International, 45 (5). pp. 997-1003.Full text not available from this repository.
Transforming growth factor-beta s (TGF-beta 5) are multifunctional polypeptides, known to influence proliferation and differentiation of many cell types. TGF-beta 5 cDNA was cloned from Xenopus laevis and this isoform is unique to the amphibians. Here, we report the isolation and characterization of the TGF-beta 5 genomic clones to determine the structure of TGF-beta 5 gene. The gene consists of seven exons and all intron-exon boundaries follow the GT-AG consensus. The organization of TGF-beta 5 gene was identical to that of the mammalian TGF-beta isoforms, with the exception of position of the first splice junction. We determined the size of TGF-beta 5 gene to be approximately 20 kb.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Academic Press Aust.|
|Keywords:||transforming growth factor-beta;intron;exon;gene structure; genomic library;Xenopus laevis.|
|Department/Centre:||Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)|
|Date Deposited:||09 Jun 2011 06:28|
|Last Modified:||09 Jun 2011 06:28|
Actions (login required)