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In vivo clearance of Japanese encephalitis virus by adoptively transferred virus specific cytotoxic T lymphocytes

Desai, A and MuraliKrishna, K and Ramireddy, B and Ravi, V and Manjunath, R (1997) In vivo clearance of Japanese encephalitis virus by adoptively transferred virus specific cytotoxic T lymphocytes. In: Journal of Biosciences, 22 (1). pp. 33-45.

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Abstract

Japanese encephalitis virus (JEV) is a positive stranded RNA virus that belongs to the flavivirus group, JEV infection damages the central nervous system (CNS) and is one of the main causative agents of acute encephalitis, H-2 restricted virus-specific cytotoxic T lymphocytes (CTL) have been generated specifically against JEV in our laboratory and these CTL have been shown to protect mice against lethal challenge with JEV, Virus replication was found to be inhibited in the brains of animals that mere adoptively transferred with JEV specific CTL as revealed by immunohistological staining as,veil as viral plaque assays. We further show that virus specific CTL could be recovered from such protected mice as long as 45 days after adoptive transfer.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Indian Academy of Sciences.
Keywords: Cytotoxic T lymphocytes;adoptive transfer;clearance in vivo;Japanese encephalitis virus.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 29 Aug 2011 10:37
Last Modified: 29 Aug 2011 10:37
URI: http://eprints.iisc.ernet.in/id/eprint/38278

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