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Regulation of progesterone biosynthesis in the human placenta by estradiol 17 beta and progesterone

Shanker, YG and Rao, AJ (1997) Regulation of progesterone biosynthesis in the human placenta by estradiol 17 beta and progesterone. In: Biochemistry & Molecular Biology International, 43 (3). pp. 591-599.

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Abstract

Ex vivo addition of estradiol 17 beta to first trimester or term human placental minces caused a significant increase in the quantity of progesterone produced. Addition of an aromatase inhibitor, CGS 16949 A or the estrogen receptor antagonist, ICI 182780, significantly inhibited progesterone production confirming the role of estradiol 17 beta in the regulation of progesterone synthesis in human placenta. RU 486 and ZK 98299, which are antagonists of progesterone receptor, significantly modulated progesterone synthesis in the human placenta but exhibited paradoxical effects on the first trimester and term placenta We conclude that progesterone synthesis in the human placenta is regulated by estradiol 17 beta and progesterone. This is the first report providing evidence for autoregulation of progesterone synthesis in the human placenta.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Academic press aust.
Department/Centre: Division of Biological Sciences > Biochemistry
Others
Date Deposited: 04 Aug 2011 05:02
Last Modified: 04 Aug 2011 05:02
URI: http://eprints.iisc.ernet.in/id/eprint/38384

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