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Is O-1(2) alone sufficient for DNA cleavage? Possible involvement of paramagnetic intermediates

Chanon, Michel and Julliard, Michel and Mehta, Goverdhan and Maiya, Bhaskar G (1999) Is O-1(2) alone sufficient for DNA cleavage? Possible involvement of paramagnetic intermediates. In: Research on Chemical Intermediates, 25 (7). pp. 633-644.

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Official URL: http://www.ingentaconnect.com/content/vsp/rci/1999...

Abstract

It is proposed that singlet dioxygen reacting with guanosine or deoxyguanosine part of nucleotides does not, by itself, cause DNA cleavage. The strand break originates at the endoperoxide stage whenever this link evolves into a O-centered radical. The O-centered radical is then in a good spatial position to abstract an hydrogen intramolecularly from the ribose or desoxyribose part of the nucleotide. The carbon centered radical thus formed on the sugar part may lead to strand break either by a p-scission mechanism or by an homolytically induced solvolysis. High pH could also induce cleavage after the endoperoxide stage via a base catalyzed ring chain protomerism.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Springer.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 23 Jun 2011 07:24
Last Modified: 23 Jun 2011 07:24
URI: http://eprints.iisc.ernet.in/id/eprint/38596

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