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Neuropeptide Y structure is modulated by aluminium in the hypothalamus

Rao, KSJ and Ramesh, J and Easwaran, KRK (1999) Neuropeptide Y structure is modulated by aluminium in the hypothalamus. In: ALZHEIMERS REPORTS, 2 (2). 99-103 .

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Official URL: http://ncsi-net.ncsi.iisc.ernet.in/gsdl/cgi-bin/li...

Abstract

Aluminium is an element suspected to contribute to the pathogenesis of Alzheimer's disease, but its mechanism of action is not clear. Neuropeptide Y (NPY) plays a significant role in feeding behaviour. Our spectroscopic, ELISA, and western blot studies indicate that aluminium interacts with neuropeptide Y and alters significantly the a-helical content. We found that aluminium reduced levels of NPY in the hypothalamus of aged rabbits. NPY polyclonal antibody interaction was found to depend upon the alpha-helical content of NPY. These results clearly show that aluminium alters NPY structure and this could explain the abnormality in feeding behaviour seen in patients with Alzheimer's disease.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to MEDICAL SCIENCE JOURNALS.
Keywords: Alzheimers disease;aluminium;circular dichroism; conformation;neuropeptide
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 30 Jun 2011 09:01
Last Modified: 30 Jun 2011 09:01
URI: http://eprints.iisc.ernet.in/id/eprint/38688

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