Rao, KSJ and Ramesh, J and Easwaran, KRK (1999) Neuropeptide Y structure is modulated by aluminium in the hypothalamus. In: ALZHEIMERS REPORTS, 2 (2). 99-103 .Full text not available from this repository.
Aluminium is an element suspected to contribute to the pathogenesis of Alzheimer's disease, but its mechanism of action is not clear. Neuropeptide Y (NPY) plays a significant role in feeding behaviour. Our spectroscopic, ELISA, and western blot studies indicate that aluminium interacts with neuropeptide Y and alters significantly the a-helical content. We found that aluminium reduced levels of NPY in the hypothalamus of aged rabbits. NPY polyclonal antibody interaction was found to depend upon the alpha-helical content of NPY. These results clearly show that aluminium alters NPY structure and this could explain the abnormality in feeding behaviour seen in patients with Alzheimer's disease.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to MEDICAL SCIENCE JOURNALS.|
|Keywords:||Alzheimers disease;aluminium;circular dichroism; conformation;neuropeptide|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||30 Jun 2011 09:01|
|Last Modified:||30 Jun 2011 09:01|
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