Chandrasekhar, Sosale and Gopalaiah, Kovuru (2002) Beckmann rearrangement of ketoximes on solid metaboric acid: a simple and effective procedure. In: Tetrahedron Letters, 43 (13). pp. 2455-2457.
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When ketoximes admixed with solid metaboric acid (formed from boric acid at 100degreesC/0.1 Torr) are heated (similar to 140degreesC/7-42 h), the corresponding amides or lactams are produced in excellent yields (62-92%) via the Beckmann reaction. Aromatic aldoximes undergo both dehydration to the nitrile as well as (non-stereospecific) rearrangement under the above conditions. The absence of solvent, and the mildness and low toxicity of boric acid, characterise the present procedure. CO. 2002 Elsevier Science Ltd. All rights reserved.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier Science.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||04 Aug 2011 05:44|
|Last Modified:||04 Aug 2011 05:44|
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