Bhattacharya, S and Thomas, M (2001) DNA recognition by the first tail-to-tail linked distamycin-like oligopeptide dimers. In: Chemical Communications (16). pp. 1464-1465.
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Sequence-specific bidentate binding to double-stranded (ds)-DNA by 'tail-to-tail' linked dimeric, distamycin analogues is described; compared to their monomeric analogues, these dimers exhibit greater affinity and longer binding site size and open up a novel avenue in the design of minor groove binders that overcome the phasing problem.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Royal Society of Chemistry.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||02 Aug 2011 06:54|
|Last Modified:||02 Aug 2011 06:54|
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