Accessing the disallowed conformations of peptides employing amide-to-imidate modification

Reddy, Damodara N and Thirupathi, Ravula and Prabhakaran, Erode N (2011) Accessing the disallowed conformations of peptides employing amide-to-imidate modification. In: Chemical Communications, 47 (33). pp. 9417-9419.

PDF Accessing_the.pdf - Published Version Restricted to Registered users only Download (1372Kb) | Request a copy

Abstract

Selective modification of the C-terminal amide in peptides to dihydrooxazine (a novel stable imidate isostere) by intramolecular nucleophilic cyclo-O-alkylation of the corresponding N-(3-bromopropyl)amides results in constraining of the C-terminal residue in natively disallowed conformations both in crystals and in solution.

Item Type:	Journal Article
Additional Information:	Copyright of this article belongs to Royal Society of Chemistry.
Department/Centre:	Division of Chemical Sciences > Organic Chemistry Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited:	16 Sep 2011 09:11
Last Modified:	16 Sep 2011 09:11
URI:	http://eprints.iisc.ernet.in/id/eprint/40563

Actions (login required)

View Item