Mehta, Goverdhan and Islam, Kabirul (2004) Enantioselective total synthesis of (−)-epoxyquinols A and B. Novel, convenient access to chiral epoxyquinone building blocks through enzymatic desymmetrization. In: Tetrahedron Letters, 45 (18). pp. 3611-3615.
Following our recent total synthesis of the biologically potent natural products epoxyquinols A and B in racemic form, we have now accomplished the total synthesis of the (−)-epoxyquinols A and B, anti-podes of the angiogenesis inhibiting natural products, through a protocol that involves enzymatic desymmetrization of a versatile epoxyquinone derivative, readily available from the Diels–Alder adduct of cyclopentadiene and p-benzoquinone.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Elsevier Science Ltd.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||21 Jun 2004|
|Last Modified:||19 Sep 2010 04:12|
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