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Conformations of Dinucleoside Monophosphates in Relation to Duplex DNA Structures

Rao, Shashidhar N and Sasisekharan, V (1986) Conformations of Dinucleoside Monophosphates in Relation to Duplex DNA Structures. In: Biopolymers, 25 (1). pp. 17-30.


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Mononucleotide conformations are important in understanding the structural aspects of nucleic acids and polynucleotides. In order to study the influence of stacking interactions between adjacent bases in a polynucleotide on the preferred conformations of mononucleotides, conformational energy calculations have been carried out on dinucleoside monophosphate fragments. Four base sequences-d(ApT), d(TpA), d(CpG), and d(GpC)- have been analyzed in the framework of helical structures. Flexibility of the furanose ring has been incorporated in the investigations. Energetically favored conformers of the four compounds correspond to a variety of left- and right-handed uniform helical structures, similar to those of the commonly observed polymorphous forms. Implications of these investigations on the further understanding of doublehelical polynucleotide conformations are briefly discussed.

Item Type: Journal Article
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Additional Information: The copyright belongs to John Wiley & Sons, Inc.
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 02 Dec 2005
Last Modified: 19 Sep 2010 04:21
URI: http://eprints.iisc.ernet.in/id/eprint/4110

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