Rao, Shashidhar N and Sasisekharan, V (1986) Conformations of Dinucleoside Monophosphates in Relation to Duplex DNA Structures. In: Biopolymers, 25 (1). pp. 17-30.
Mononucleotide conformations are important in understanding the structural aspects of nucleic acids and polynucleotides. In order to study the influence of stacking interactions between adjacent bases in a polynucleotide on the preferred conformations of mononucleotides, conformational energy calculations have been carried out on dinucleoside monophosphate fragments. Four base sequences-d(ApT), d(TpA), d(CpG), and d(GpC)- have been analyzed in the framework of helical structures. Flexibility of the furanose ring has been incorporated in the investigations. Energetically favored conformers of the four compounds correspond to a variety of left- and right-handed uniform helical structures, similar to those of the commonly observed polymorphous forms. Implications of these investigations on the further understanding of doublehelical polynucleotide conformations are briefly discussed.
|Item Type:||Journal Article|
|Additional Information:||The copyright belongs to John Wiley & Sons, Inc.|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||02 Dec 2005|
|Last Modified:||19 Sep 2010 04:21|
Actions (login required)