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Iodine-Catalyzed Amination of Benzoxazoles: A Metal-Free Route to 2-Aminobenzoxazoles under Mild Conditions

Lamani, Manjunath and Prabhu, Kandikere Ramaiah (2011) Iodine-Catalyzed Amination of Benzoxazoles: A Metal-Free Route to 2-Aminobenzoxazoles under Mild Conditions. In: Journal of Organic Chemistry, 76 (19). pp. 7938-7944.

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Official URL: http://pubs.acs.org/doi/abs/10.1021/jo201402a

Abstract

A facile metal-free route of oxidative amination of benzoxazole by activation of C-H bonds with secondary or primary amines in the presence of catalytic iodine in aqueous tert-butyl hydroperoxide proceeds smoothly at ambient temperature under neat reaction condition to furnish the high yield of the aminated product. This user-friendly method to form C-N bonds produces tertiary butanol and water as the byproduct, which are environmentally benign. The application of the methodology is demonsrated by synthesizing therapeutically active benzoxazoles.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to American Chemical Society.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 08 Nov 2011 11:45
Last Modified: 08 Nov 2011 11:45
URI: http://eprints.iisc.ernet.in/id/eprint/41928

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