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Antihyperlipidemic potential of Cedrus deodara extracts in monosodium glutamate induced obesity in neonatal rats

Patil, Sudhir and Prakash, T and Kotresha, D and Rao, Rama N and Pandy, Naitik (2011) Antihyperlipidemic potential of Cedrus deodara extracts in monosodium glutamate induced obesity in neonatal rats. In: Indian Journal of Pharmacy, The, 43 (6). pp. 644-647.

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Abstract

Objective: To study the antihyperlipidemic effect of Cedrus deodara (C. deodara) against monosodium glutamate (MSG) induced obesity in neonatal rats. Materials and Methods: The studies were carried out on newborn neonatal rats and were injected intraperitoneally with 2 mg/g of MSG on the 2(nd) and 4(th) postnatal days and 4 mg/g on 6(th), 8(th) and 10(th) postnatal days. Ethanolic extract (EE) and acetone extract (AE) of C. deodara was administered in a dose of 100 and 200 mg/kg, p.o./day at the age of 65 days. On day 60 of treatment, body weight, locomotor activity, body temperature, and various biochemical parameters like serum glucose, total cholesterol, triglyceride, and organs weights were recorded. Results: There was a significant reduction in body weight, organs and increased body temperature, locomotor activity after treatment with extracts. C. deodara decreased serum glucose, total cholesterol and triglyceride, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels and increased high density lipoprotein (HDL) significantly has compared to MSG-control rats. Conclusion: C. deodara extracts exhibited antihyperlipidemic effect and it possesses anti-obesity properties in MSG induced obese rats.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to the Authors
Keywords: Antihyperlipidemic;Cedrus deodara;monosodium glutamate; neonatal;obesity
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 20 Dec 2011 11:48
Last Modified: 20 Dec 2011 11:48
URI: http://eprints.iisc.ernet.in/id/eprint/42777

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