Nath, Nilamoni and Hebbar, Sankeerth and Prabhu, Uday Ramesh and Suryaprakash, N (2010) Oneand twodimensional single quantumand multiplequantumNMR methodologies: tools for chiral analyses. In: Journal of the Indian Institute of Science, 90 (1). pp. 1-36.
Oneand_twodimensional.pdf - Published Version
It is well known that enantiomers cannot be distinguished by NMR spectroscopy unless diastereomorphic interactions are imposed. Several chiral aligning media have therefore been reported for their visualization, although extensive studies are carried out using the liquid crystal made of polypeptide poly-γ-benzyl-L-glutamate (PBLG) in organic solvent. In PBLG medium the spin systems are weakly coupled and the first order analyses of the spectra are generally possible. But due to large number of pair wise interactions of nuclear spins resulting in many degenerate transitions the 1H NMR spectra are not only complex but also broad and featureless, in addition to an indistinguishable overlap of the spectra of enantiomers. This enormous loss of resolution severely hinders the analyses of proton spectra, even for spin systems with 5–6 interacting protons, thereby restricting itsroutine application. In this review we discuss our recently developed several one and multidimensional NMR experiments to circumvent these difficulties taking specific examples of the molecules containing a single chiral centre.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to The Indian Institute of Science (IISc).|
|Department/Centre:||Division of Chemical Sciences > Solid State & Structural Chemistry Unit|
|Date Deposited:||09 Feb 2012 09:49|
|Last Modified:||09 Feb 2012 09:49|
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