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Biological and materials properties of various cholesterol based systems

Biswas, Joydeep and Raja, Guru V and Bhattacharya, Santanu (2009) Biological and materials properties of various cholesterol based systems. In: Journal of the Indian Institute of Science, 89 (2).

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Abstract

Liposomes composed of cationic lipids have become very popular gene delivery vehicles. A great deal of research is being pursued to make efficient vectors by varying their molecular architecture. Cholesterol being ubiquitous component in most of the animal cell membranes is increasingly being used as a hydrophobic segment of synthetic cationic lipids. In this review we describe various cholesterol based cationic lipids and focus on the effect of modifying various structural segments like linker and the head group of the cationic lipids on gene transfection efficiency with a special emphasis on the importance of ether linkage between cholesteryl backbone and the polar head group. Interaction of cationic cholesteryl lipids with dipalmitylphosphatidycholine membranes is also discussed here. Apart from cholesterol being an attractive scaffold in the drug/gene delivery vehicles, certain cholesteryl derivatives have also been shown to be attractive room temperature liquid-crystalline materials.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to The Indian Institute of Science (IISc).
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 09 Feb 2012 09:23
Last Modified: 09 Feb 2012 09:23
URI: http://eprints.iisc.ernet.in/id/eprint/43339

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