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Synthesis and Antileukemic Activity of Novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piper idin-1-yl)ethanone Derivatives

Vinaya, Kambappa and Kavitha, Chandagirikoppal V and Prasanna, Doddakunche S and Chandrappa, Siddappa and Ranganatha, Somasagara R and Raghavan, Sathees C and Rangappa, Kanchugarakoppal S (2012) Synthesis and Antileukemic Activity of Novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piper idin-1-yl)ethanone Derivatives. In: Chemical Biology & Drug Design, 79 (3). pp. 360-367.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1747-...

Abstract

A series of novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl) piperidin-1-yl)ethanone derivatives 9(ae) and 10(ag) were synthesized and characterized by 1H NMR, IR, mass spectral, and elemental analysis. These novel compounds were evaluated for their antileukemic activity against two human leukemic cell lines (K562 and CEM) by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay. Some of the tested compounds showed good antiproliferative activity with IC50 values ranging from 1.6 to 8.0 mu m. Compound 9c, 9e, and 10f with an electron-withdrawing halogen substituent at the para position on the phenyl ring showed excellent in vitro potency against tested human leukemia cells (K562 and CEM).

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: 1, 3-dimethoxy benzene;anticancer agents;cell death; leukemia;MTT assay;piperidine
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 22 Feb 2012 11:26
Last Modified: 22 Feb 2012 11:26
URI: http://eprints.iisc.ernet.in/id/eprint/43520

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