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Evaluation of physico-mechanical properties and in vitro biocompatibility of compression molded HDPE based biocomposites with HA/Al2O3 ceramic fillers and titanate coupling agents

Tripathi, Garima and Dubey, Ashutosh Kumar and Basu, Bikramjit (2012) Evaluation of physico-mechanical properties and in vitro biocompatibility of compression molded HDPE based biocomposites with HA/Al2O3 ceramic fillers and titanate coupling agents. In: Journal of Applied Polymer Science, 124 (4). pp. 3051-3063.

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/app.353...

Abstract

The present article demonstrates how the stiffness, hardness as well as the cellular response of bioinert high-density polyethylene (HDPE) can be significantly improved with combined addition of both bioinert and bioactive ceramic fillers. For this purpose, different amounts of hydroxyapatite and alumina, limited to a total of 40 wt %, have been incorporated in HDPE matrix. An important step in composite fabrication was to select appropriate solvent and optimal addition of coupling agent (CA). In case of chemically coupled composites, 2% Titanium IV, 2-propanolato, tris iso-octadecanoato-O was used as a CA. All the hybrid composites, except monolithic HDPE, were fabricated under optimized compression molding condition (140 degrees C, 0.75 h, 10 MPa pressure). The compression molded composites were characterized, using X-ray diffraction, Fourier transformed infrared spectroscopy, and scanning electron microscopy. Importantly, in vitro cell culture and cell viability study (MTT) using L929 fibroblast and SaOS2 osteoblast-like cells confirmed good cytocompatibility properties of the developed hybrid composites. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012

Item Type: Journal Article
Additional Information: Copyright of this article belongs to John Wiley and Sons.
Keywords: HDPE;composite;coupling agent;microstructure;cell adhesion
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Date Deposited: 12 Mar 2012 09:06
Last Modified: 12 Mar 2012 09:06
URI: http://eprints.iisc.ernet.in/id/eprint/43695

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