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Cytocompatibility property evaluation of gas pressure sintered SiAlON-SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells

Kumar, Alok and Mallik, Awadesh Kumar and Acikbas, Nurcan Calis and Yaygingol, Merve and Kara, Ferhat and Mandal, Hasan and Basu, Debabrata and Biswas, Krishanu and Basu, Bikramjit (2012) Cytocompatibility property evaluation of gas pressure sintered SiAlON-SiC composites with L929 fibroblast cells and Saos-2 osteoblast-like cells. In: Materials Science and Engineering: C, 32 (3). pp. 464-469.

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Official URL: http://dx.doi.org/10.1016/j.msec.2011.11.019

Abstract

Although the oxide ceramics have widely been investigated for their biocompatibility, non-oxide ceramics, such as SiAlON and SiC are yet to be explored in detail. Lack of understanding of the biocompatibility restricts the use of these ceramics in clinical trials. It is hence, essential to carry out proper and thorough study to assess cell adhesion, cytocompatibility and cell viability on the non-oxide ceramics for the potential applications. In this perspective, the present research work reports the cytocompatibility of gas pressure sintered SiAlON monolith and SiAlON-SiC composites with varying amount of SIC, using connective tissue cells (L929) and bone cells (Saos-2). The quantification of cell viability using MTT assay reveals the non-cytotoxic response. The cell viability has been found to be cell type dependent. An attempt has been made to discuss the cytocompatibility of the developed composites in the light of SiC content and type of sinter additives. (C) 2011 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science B.V.
Keywords: SiAlON;SiC;Composite;In vitro;Cytocompatibility
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Date Deposited: 13 Apr 2012 10:46
Last Modified: 13 Apr 2012 10:46
URI: http://eprints.iisc.ernet.in/id/eprint/44246

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