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Molybdenum trioxide catalyzed oxidative cross-dehydrogenative coupling of benzylic sp(3) C-H bonds: synthesis of alpha-aminophosphonates under aerobic conditions

Alagiri, Kaliyamoorthy and Devadig, Pradeep and Prabhu, Kandikere R (2012) Molybdenum trioxide catalyzed oxidative cross-dehydrogenative coupling of benzylic sp(3) C-H bonds: synthesis of alpha-aminophosphonates under aerobic conditions. In: Tetrahedron Letters, 53 (12). pp. 1456-1459.

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Official URL: http://dx.doi.org/10.1016/j.tetlet.2012.01.031

Abstract

Molybdenum trioxide (MoO3) catalyzed efficient oxidative cross-dehydrogenative-coupling (CDC) method for C-H functionalization of N-aryl tetrahydroisoquinolines has been explored. This user-friendly method of synthesizing alpha-aminophosphonates employs 1.1 equiv of dialkyl-H-phosphonate under aerobic condition. Formation of new C-P bonds from unfunctionalized starting materials under environmentally benign conditions provides an excellent avenue for the synthesis of biologically active alpha-aminophosphonates. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: CDC reaction;Aerobic oxidation;C-H functionalization; Molybdenum;Hydrophosphorylation
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 17 Apr 2012 11:28
Last Modified: 17 Apr 2012 11:28
URI: http://eprints.iisc.ernet.in/id/eprint/44248

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