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Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents

Karuvalam, Ranjith P and Haridas, Karickal R and Nayak, Susanta K and Row, Tayur Guru N and Rajeesh, P and Rishikesan, R and Kumari, N. Suchetha (2012) Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents. In: European Journal of Medicinal Chemistry, 49 . pp. 172-182.

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Official URL: http://dx.doi.org/10.1016/j.ejmech.2012.01.008

Abstract

A series of (2-aminothiazol-4-yl)methylester (5a-t) derivatives were synthesized in good yields and characterized by H-1 NMR, C-13 NMR, mass spectral and elemental analyses. The crystal structure of 5a was evidenced by X-ray diffraction study. The compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity. (C) 2012 Elsevier Masson SAS. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier Science.
Keywords: Thiazole;Antibacterial activity;Antifungal activity; Antimycobacterial;X-ray crystallography
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 12 May 2012 10:21
Last Modified: 12 May 2012 10:23
URI: http://eprints.iisc.ernet.in/id/eprint/44395

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