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Total Synthesis of (+)-Eburnamonine

Prasad, Kavirayani R and Nidhiry, John E. (2012) Total Synthesis of (+)-Eburnamonine. In: SYNLETT, 23 (10). pp. 1477-1480.

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Official URL: http://dx.doi.org/10.1055/s-0031-1291143

Abstract

The enantiospecific total synthesis of vinca alkaloid (+)-eburnamonine is accomplished from L-ethyl lactate. Key feature of the synthesis is the construction of the chiral quaternary center involving a Johnson-Claisen rearrangement and assembly of the pentacyclic core by the Pictet-Spengler reaction and ring-closing metathesis.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Georg Thieme Verlag KG
Keywords: eburnamonine; alkaloids; L-ethyl lactate
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 23 Jul 2012 12:13
Last Modified: 23 Jul 2012 12:15
URI: http://eprints.iisc.ernet.in/id/eprint/44808

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