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Synthesis of Cholic Acid Oligomer-Taurine Conjugates: A Study of Their Aggregation and Cholesterol Solubilization

Satyanarayana, TBN and Maitra, Uday and Savyasachi, AJ (2012) Synthesis of Cholic Acid Oligomer-Taurine Conjugates: A Study of Their Aggregation and Cholesterol Solubilization. In: European Journal of Organic Chemistry (19). pp. 3658-3664.

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Official URL: http://dx.doi.org/10.1002/ejoc.201200312

Abstract

Taurine conjugates of two cholic acid derived oligomers with different spacers between the cholic acid units were synthesized. These molecules self-assemble in aqueous media. The critical micelle concentration (CMC) values were measured by using fluorescence spectroscopic analysis and the aggregates were characterized by dynamic light scattering and electron microscopy. The cooperativity of the cholic acid units in these tetramers to solubilize cholesterol was investigated. The ability of these molecules to act as nanocarriers for liphophilic dyes was also studied.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the John Wiley and Sons.
Keywords: Medicinal chemistry;Structural biology;Drug conjugates; Aggregation;Micelles;Nanostructures;Surfactants;Cholesterol
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 23 Jul 2012 12:34
Last Modified: 23 Jul 2012 12:34
URI: http://eprints.iisc.ernet.in/id/eprint/44818

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