Afzal, Mohammad Atif Faiz and Kesarwani, Pallavi and Reddy, Madhav K and Kalmodia, Sushma and Basu, Bikramjit and Balani, Kantesh (2012) Functionally graded hydroxyapatite-alumina-zirconia biocomposite: Synergy of toughness and biocompatibility. In: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 32 (5). pp. 1164-1173.
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Functionally Gradient Materials (FGM) are considered as a novel concept to implement graded functionality that otherwise cannot be achieved by conventional homogeneous materials. For biomedical applications, an ideal combination of bioactivity on the material surface as well as good physical property (strength/toughness/hardness) of the bulk is required in a designed FGM structure. In this perspective, the present work aims at providing a smooth gradation of functionality (enhanced toughening of the bulk, and retained biocompatibility of the surface) in a spark plasma processed hydroxyapatite-alumina-zirconia (HAp-Al2O3-YSZ) FGM bio-composite. In the current work HAp (fracture toughness similar to 1.5 MPa.m(1/2)) and YSZ (fracture toughness similar to 62 MPa.m(1/2)) are coupled with a transition layer of Al2O3 allowing minimum gradient of mechanical properties (especially the fracture toughness similar to 3.5 MPa.m(1/2)).The in vitro cyto-compatibilty of HAp-Al2O3-YSZ FGM was evaluated using L929 fibroblast cells and Saos-2 Osteoblast cells for their adhesion and growth. From analysis of the cell viability data, it is evident that FGM supports good cell proliferation after 2, 3, 4 days culture. The measured variation in hardness, fracture toughness and cellular adhesion across the cross section confirmed the smooth transition achieved for the FGM (HAp-Al2O3-YSZ) nanocomposite, i.e. enhanced bulk toughness combined with unrestricted surface bioactivity. Therefore, such designed biomaterials can serve as potential bone implants. (C) 2012 Elsevier B.V. All rights reserved.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Elsevier|
|Keywords:||Functionally graded HAp-Al2O3-YSZ;Spark plasma sintering;Fracture toughness; Cell culture;MTT assay|
|Department/Centre:||Division of Chemical Sciences > Materials Research Centre|
|Date Deposited:||30 Jul 2012 05:45|
|Last Modified:||30 Jul 2012 05:45|
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