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Catalytic Asymmetric Synthesis of alpha,beta-Disubstituted alpha,gamma-Diaminophosphonic Acid Precursors by Michael Addition of alpha-Substituted Nitrophosphonates to Nitroolefins

Tripathi, Chandra Bhushan and Kayal, Satavisha and Mukherjee, Santanu (2012) Catalytic Asymmetric Synthesis of alpha,beta-Disubstituted alpha,gamma-Diaminophosphonic Acid Precursors by Michael Addition of alpha-Substituted Nitrophosphonates to Nitroolefins. In: ORGANIC LETTERS, 14 (13). pp. 3296-3299.

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Official URL: http://dx.doi.org/10.1021/ol3012666

Abstract

Michael additions of alpha-substituted nitrophosphonates to various nitroolefins are shown to proceed with high diastereo- and enantioselectivity when catalyzed by a quinine-derived thiourea-tertiary amine bifunctional catalyst and generate alpha,gamma-diaminophosphonic acid precursors with contiguous quaternary and tertiary stereocenters.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the AMER CHEMICAL SOC
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 09 Aug 2012 11:29
Last Modified: 09 Aug 2012 11:29
URI: http://eprints.iisc.ernet.in/id/eprint/44921

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