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Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation

Banerjee, Samya and Prasad, Puja and Hussain, Akhtar and Khan, Imran and Kondaiah, Paturu and Chakravarty, Akhil R. (2012) Remarkable photocytotoxicity of curcumin in HeLa cells in visible light and arresting its degradation on oxovanadium(IV) complex formation. In: CHEMICAL COMMUNICATIONS, 48 (62). pp. 7702-7704.

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Official URL: http://dx.doi.org/10.1039/c2cc33576j

Abstract

Curcumin (Hcur) as a cellular imaging and PDT agent shows remarkable photocytotoxicity in HeLa cells in visible light of 400-700 nm giving IC50 = 8.2 +/- 0.2 mu M and its degradation is arrested on formation of photocytotoxic dipyridophenazine (dppz) complex VO(cur)(dppz)Cl] (IC50 = 3.3 +/- 0.4 mu M), while both are less toxic in the dark.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the ROYAL SOC. of CHEMISTRY
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics (formed by the merger of DBGL and CRBME)
Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 08 Aug 2012 08:43
Last Modified: 08 Aug 2012 08:43
URI: http://eprints.iisc.ernet.in/id/eprint/44929

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