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Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility

Katapadi, Vijeth K and Nambiar, Mridula and Raghavan, Sathees C (2012) Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility. In: GENOMICS, 100 (2). pp. 72-80.

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Official URL: http://dx.doi.org/10.1016/j.ygeno.2012.05.008

Abstract

Genetic alterations like point mutations, insertions, deletions, inversions and translocations are frequently found in cancers. Chromosomal translocations are one of the most common genomic aberrations associated with nearly all types of cancers especially leukemia and lymphoma. Recent studies have shown the role of non-B DNA structures in generation of translocations. In the present study, using various bioinformatic tools, we show the propensity of formation of different types of altered DNA structures near translocation breakpoint regions. In particular, we find close association between occurrence of G-quadruplex forming motifs and fragile regions in almost 70% of genes involved in rearrangements in lymphoid cancers. However, such an analysis did not provide any evidence for the occurrence of G-quadruplexes at the close vicinity of translocation breakpoint regions in nonlymphoid cancers. Overall, this study will help in the identification of novel non-B DNA targets that may be responsible for generation of chromosomal translocations in cancer. (C) 2012 Elsevier Inc. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Elsevier SCience
Keywords: Genomic instability; Double-strand break; Altered DNA structures; DNA damage; Nonhomologous DNA end joining; Chromosomal translocation
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 28 Aug 2012 07:12
Last Modified: 28 Aug 2012 07:12
URI: http://eprints.iisc.ernet.in/id/eprint/44972

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