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Structural characterization of backbone-expanded helices in hybrid peptides: (αγ) n and (αβ) n sequences with unconstrained β and γ homologues of L-Val

Basuroy, Krishnayan and Dinesh, Bhimareddy and Shamala, Narayanaswamy and Balaram, Padmanabhan (2012) Structural characterization of backbone-expanded helices in hybrid peptides: (αγ) n and (αβ) n sequences with unconstrained β and γ homologues of L-Val. In: Angewandte Chemie - International Edition, 51 (35). pp. 8736-8739.

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Official URL: http://dx.doi.org/10.1002/anie.201204436

Abstract

Learning your αβγ's: The diversity of hydrogen-bonding patterns in backbone-expanded hybrid helices is shown by crystal-structure determination of several oligomeric peptides (see scheme; C=gray; H=white; O=red; N=blue). C 12 helices were observed in the αγ peptide series for n=2-8. In comparison, the αα peptide and αβ peptide sequences show C 10 and mixed C 14/C 15 helices, respectively. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to the John Wiley and Sons
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 13 Sep 2012 08:48
Last Modified: 13 Sep 2012 08:48
URI: http://eprints.iisc.ernet.in/id/eprint/45047

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