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An efficient one-pot synthesis and photoinduced DNA cleavage studies of 2-chloro-3-(5-aryl-4,5-dihydroisoxazol-3-yl)quinolines

Bindu, PJ and Mahadevan, KM and Naik, Ravikumar TR (2012) An efficient one-pot synthesis and photoinduced DNA cleavage studies of 2-chloro-3-(5-aryl-4,5-dihydroisoxazol-3-yl)quinolines. In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22 (19). pp. 6095-6098.

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Official URL: http://dx.doi.org/10.1016/j.bmcl.2012.08.034

Abstract

4,5-Dihydroisoxazoles continue to attract considerable interest due to their wide spread biological activities. Here, we identify an efficient protocol for the preparation of 4,5-dihydroisoxazoles (2-isaxazolines) (4a-g) from quinolinyl chalcones. The nucleolytic activities of synthesized compounds were investigated by agarose gel electrophoresis. All these compounds were showed the remarkable DNA cleavage activity (concentration dependent) with pUC19 DNA at 365 nm UV light. The DNA cleavage activity was significantly enhanced by the presence of iminyl and carboxy radicals of DIQ. (C) 2012 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND
Keywords: Quinolinyl chalcones (QCs);2-Chloro-3-(5-aryl-4,5-dihydroisoxazol-3yl)quinolines (DIQs);DNA;Photo cleavage
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 10 Dec 2012 06:49
Last Modified: 10 Dec 2012 06:49
URI: http://eprints.iisc.ernet.in/id/eprint/45312

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