ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities

Thomas, Sajesh P and Nagarajan, K and Row, Guru TN (2012) Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities. In: CHEMICAL COMMUNICATIONS, 48 (85). pp. 10559-10561.

[img] PDF
che_com_48-85_10559_2012.pdf - Published Version
Restricted to Registered users only

Download (1998Kb) | Request a copy
[img] PDF
c2cc34912d.pdf - Published Supplemental Material
Restricted to Registered users only

Download (3485Kb) | Request a copy
[img] Plain Text
c2cc34912d.txt - Published Supplemental Material
Restricted to Registered users only

Download (84Kb) | Request a copy
Official URL: http://dx.doi.org/10.1039/c2cc34912d

Abstract

Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employed to detect the presence of a polymorphic impurity in a mixture of polymorphs.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to ROYAL SOC CHEMISTRY
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Date Deposited: 09 Nov 2012 12:09
Last Modified: 09 Nov 2012 12:11
URI: http://eprints.iisc.ernet.in/id/eprint/45331

Actions (login required)

View Item View Item